NCL Data2026 · dataset
Supplementary file 1_Metabolic memory in diabetic complications: evidence for persistent cellular states and limits of therapeutic reversal.docx<p>Metabolic memory is defined here as an exposure-history-dependent cellular phenotype that persists beyond immediate carry-over after verified withdrawal of the initiating exposure, principally high glucose and is accompanied by a specified functional impairment or an altered response to the same defined secondary stimulus. This operational definition separates cellular memory from clinical lega
NCL Data2026 · dataset
Table 1_Recurrent implantation failure: a registry-corroborated, age-stratified definition and pragmatic five-tiered management algorithm.docx<p>Recurrent implantation failure (RIF) remains a significant challenge in reproductive medicine, imposing substantial emotional, clinical, and financial burden on affected couples. RIF is generally defined as failure to achieve pregnancy after multiple transfers of good-quality embryos, yet progress in the field has been constrained by the absence of a universally accepted definition and by the i
NCL Data2026 · dataset
Supplementary file 1_Beta-cell replacement for type 1 diabetes: integrating cell products, engraftment and immune protection.docx<p>Beta-cell replacement aims to restore endogenous, glucose-responsive insulin secretion in type 1 diabetes. Donor-islet transplantation has shown that this approach can improve glycaemic control and prevent severe hypoglycaemia. Its wider use is limited by donor supply, early graft loss and chronic systemic immunosuppression. Pluripotent stem cells provide a renewable source of pancreatic progen
NCL Data2026 · dataset
<b>A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts</b><p dir="ltr">Bone metastases (BoM) develop in 60–90% of men with advanced prostate cancer (PCa) and are associated with a significantly decreased quality of life and 5-fold increased risk of mortality. However, current frontline treatments offer only marginal improvements in survival and symptom management. In this study, we investigated the metabolic landscape of BoM lesions of PCa and found that
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Data Sheet 1_Healthy sleep pattern is associated with reduced risk of incident thyroid disease: a prospective cohort study from the UK Biobank.docxIntroduction<p>The longitudinal association between sleep behaviors and the incidence of various thyroid diseases remains unclear. This study aimed to prospectively investigate the association between a healthy sleep score and the risk of incident thyroid diseases using data from the UK Biobank.</p>Methods<p>This prospective cohort study included 499, 084 adults aged 37–73 years from the UK Bioban
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_Differences in urinary biomarker profiles in patients with nephrotic-range proteinuria with and without hypoalbuminemia: a single-center cross-sectional study.docxBackground<p>Patients with chronic kidney disease (CKD) presenting as nephrotic-range proteinuria (NR, ≥3.5g/d) exhibit distinct clinical phenotypes with and without hypoalbuminemia. The underlying mechanisms need further investigation.</p>Methods<p>This retrospective study included patients with CKD hospitalized over the past two years with baseline 24-hour urine total protein (24-hUTP) exceeding
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Male reproductive health under environmental, pharmacological, and disease influences: a scoping review.docx<p>Male reproductive health reflects coordinated spermatogenesis, endocrine regulation, reproductive-tract patency, sexual function, and sperm genomic integrity. This scoping review maps evidence on environmental exposures, pharmacological agents and substance use, and acute or chronic diseases that may influence these domains, with emphasis on biological mechanisms, clinical assessment, preventio
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Data Sheet 1_Outcome-specific value of longitudinal clinical information and model complexity for dynamic prediction of type 2 diabetes-related outcomes: a pooled landmarking study.pdfObjective<p>To evaluate the outcome-specific incremental value of longitudinal clinical history and model complexity for annual dynamic prediction of multiple type 2 diabetes-related outcomes using pooled landmarking.</p>Methods<p>We included 646 patients with complete annual records from baseline through year 3. Landmark times at years 1 and 2 were used to predict the first recorded occurrence of
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_NADPH oxidase 4 as a source of hydrogen peroxide can regulate norepinephrine levels and vascular contraction.docxIntroduction<p>The adrenal glands play a pivotal role in maintaining physiological homeostasis, and disturbance in their function can lead to significant clinical disorders, including hypertension, and adrenal insufficiency. Reactive oxygen species (ROS), once considered merely byproducts of cellular metabolism, are now recognized as critical signaling molecules within the adrenal cortex and medul
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 2_Sex-specific hormone signatures in four fish species with divergent reproductive strategies.xlsxIntroduction<p>Steroid hormones regulate diverse biological processes, including development, immunity and reproduction. Because biological sex, pregnancy, parental care, and mate competition are closely associated in most established model organisms, it remains unclear whether endocrine differences between males and females are primarily linked to gametic sex or to the reproductive roles performe
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_Sex-specific hormone signatures in four fish species with divergent reproductive strategies.docxIntroduction<p>Steroid hormones regulate diverse biological processes, including development, immunity and reproduction. Because biological sex, pregnancy, parental care, and mate competition are closely associated in most established model organisms, it remains unclear whether endocrine differences between males and females are primarily linked to gametic sex or to the reproductive roles performe
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_A nested case-control study on the relationship between gut microbiota and non-alcoholic fatty liver disease.docxBackground<p>The gut microbiota plays an important role in non-alcoholic fatty liver disease (NAFLD). This study aimed to explore gut microbiota-associated biomarkers for incident NAFLD and evaluate their predictive value, providing preliminary evidence for early risk identification.</p>Methods<p>From an initial cohort of 1,772 participants, 404 were included in the final analysis, comprising 101
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Sex-specific hormone signatures in four fish species with divergent reproductive strategies.xlsxIntroduction<p>Steroid hormones regulate diverse biological processes, including development, immunity and reproduction. Because biological sex, pregnancy, parental care, and mate competition are closely associated in most established model organisms, it remains unclear whether endocrine differences between males and females are primarily linked to gametic sex or to the reproductive roles performe
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Peritoneal neuroendocrine carcinoma of unknown primary with markedly elevated alpha-fetoprotein: a case report.docxBackground<p>Peritoneal neuroendocrine carcinoma(NEC) is primarily metastatic, with primary cases being exceedingly rare. The relationship between alpha-fetoprotein(AFP) and neuroendocrine carcinoma remains unclear. In this report, we present a patient with peritoneal neuroendocrine carcinoma who exhibited significantly elevated AFP levels. Extensive evaluation revealed no obvious primary site out
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Microglia as candidate links between hormonal signals and neuronal circuits in polycystic ovary syndrome: evidence gaps and a research agenda.docx<p>Polycystic ovary syndrome (PCOS) combines reproductive endocrine dysfunction with metabolic, autonomic, and neurobehavioral phenotypes, yet the contribution of brain microglia remains uncertain. We conducted a structured narrative review that separates human PCOS evidence, PCOS-like animal findings, PCOS-related cellular observations, and non-PCOS mechanistic bridges. Only three heterogeneous P
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_CagriSema versus Semaglutide 2.4 mg monotherapy for weight management in adults with overweight or obesity, with or without type 2 diabetes: a systematic review, meta-analysis, and trial sequential analysis.docxIntroduction<p>Semaglutide 2.4 mg is the reference pharmacotherapy for weight management, yet many patients do not reach ambitious weight-loss targets. CagriSema, a fixed-dose combination of cagrilintide and semaglutide, may offer additional benefit through complementary mechanisms. We quantified its incremental efficacy and safety against semaglutide 2.4 mg monotherapy in adults with overweight o
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Data Sheet 1_Association between triglyceride-glucose index and stages of T2DM: potential indirect effects of inflammatory indicators.pdfBackground<p>The triglyceride-glucose (TyG) index is a reliable surrogate marker of insulin resistance and has been closely linked to type 2 diabetes mellitus (T2DM) risk. However, it remains unclear whether the TyG index is nonlinearly associated with cross-sectional glycemic status categories, from normal glucose to T2DM, and whether inflammatory indicators may partly account for this associatio
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 3_Sex-specific hormone signatures in four fish species with divergent reproductive strategies.xlsxIntroduction<p>Steroid hormones regulate diverse biological processes, including development, immunity and reproduction. Because biological sex, pregnancy, parental care, and mate competition are closely associated in most established model organisms, it remains unclear whether endocrine differences between males and females are primarily linked to gametic sex or to the reproductive roles performe
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Accuracy, potential harm, weight stigma, and commercial influence in short-form social media content on incretin-based therapies for obesity.docxBackground<p>Short-form video platforms such as TikTok and YouTube Shorts are major sources of health information, yet little is known about the reliability of what they carry on incretin-based therapies for obesity. We assessed the accuracy, safety, obesity-related stigma, and commercial nature of short-form videos on these medications.</p>Methods<p>We conducted a cross-sectional content analysis
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_Early-admission serum albumin and hospitalization burden in a selected serial-culture cohort of patients with diabetic foot ulcers and subsequent Pseudomonas aeruginosa detection: a retrospective cohort study.docxBackground<p>Patients with diabetic foot ulcers (DFUs) who undergo repeat wound culture and subsequent Pseudomonas aeruginosa (PA) detection form a selected clinical trajectory. Early-admission serum albumin reflects inflammation, capillary permeability, hepatic synthesis, protein loss, hydration, and nutritional reserve; it is not a stand-alone measure of nutritional status. We examined its assoc
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
<b>Supplementary datasets for: </b><b>BdCDPK5 is an essential regulator of </b><b><i>Babesia divergens</i></b><b> intraerythrocytic progression</b><p dir="ltr">Consensus sequences of the four <i>bdcdpk</i> genes and detailed maps of the episomal and knockout plasmids.</p>
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_Integrative transcriptomics and metabolomics reveal Cry1-associated hepatic alterations and plasma essential fatty acids as biomarkers of residual circadian disruption post-sepsis.docxBackground<p>Sepsis disrupts circadian rhythm, leaving lasting molecular traces and circadian insensitivity to jet lag even after acute phase recovery. However, the core mechanism and biomarkers of residual circadian dysfunction post-sepsis remain unclear, which hinders targeted interventions.</p>Methods<p>Male mice were subjected to non-lethal LPS injection, and after 7 days of recovery, liver tr
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Table 1_Inverse association between the extracellular matrix protein Tenascin-X and concurrent abdominal aortic calcification in patients with primary aldosteronism.docxBackground<p>Patients diagnosed with primary aldosteronism (PA) are at significantly increased risk of abdominal aortic calcification (AAC) and subsequent cardiovascular complications. Notably, abdominal aortic calcification is independently associated with adverse cardiovascular outcomes. However, to date, no serum proteomic profiling has been specially carried out in PA patients complicated with
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Dataset for Lake et al. MGO CK paper<p dir="ltr">Data set to match posted preprint by Rahiim Lake, Sergiy Nadtochiy, Paul Brookes. Paper on methylglyoxal (MGO) and creatine kinase (CK).</p>
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Supplementary file 1_The predictive value of glycated CD59 for fetal overgrowth in second-trimester pregnant women.docxObjective<p>To investigate the predictive value of glycated CD59 (gCD59) during mid-pregnancy for adverse pregnancy outcomes, specifically macrosomia and large for gestational age (LGA), in a prospective cohort of pregnant women undergoing oral glucose tolerance testing (OGTT), with adjustment for gestational diabetes mellitus (GDM) status.</p>Methods<p>A total of 672 pregnant women who attended p