NCL Data2026 · dataset
<b>A lactate-fatty acid loop drives prostate cancer bone colonization by mediating metabolic interplay between tumor cells and osteoblasts</b><p dir="ltr">Bone metastases (BoM) develop in 60–90% of men with advanced prostate cancer (PCa) and are associated with a significantly decreased quality of life and 5-fold increased risk of mortality. However, current frontline treatments offer only marginal improvements in survival and symptom management. In this study, we investigated the metabolic landscape of BoM lesions of PCa and found that
ZivaHub + HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue
RDS object from Defensin_manuscript_figure_reproduction_scRNAseq_Foti_Zychlinsky<p dir="ltr">RDS object (20250919_pbmc.rds) that is a dependency for https://github.com/bihealth/Defensin_manuscript_figure_reproduction_scRNAseq_Foti_Zychlinsky</p><p dir="ltr">Processed count matrices are deposited at GEO here:</p><p dir="ltr">GSE344857</p>
HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Astronomical catalogue
Raw movie of a typical single-molecule TIRF experiment. These data fully demonstrate stochastic transitions of the V-ATPase between active and inactive modes and their regulation by specific inhibitor Bafilomycin A1.<h4 dir="ltr">This video shows single-molecule acidification kinetics of native vacuolar-type ATPase (V-ATPase) in individual synaptic vesicles (SVs) purified from rat brain, labeled with the pH-sensitive lipid pHrodo-DOPE and imaged by total internal reflection fluorescence (TIRF) microscopy (Olympus TIRF system, 532 nm excitation, iXon 897 EMCCD camera, 500 ms exposure per frame, 3 s cycle time)
figshare2026 · Astronomical catalogue
Supporting data to Table 1 of the recently submitted manuscript titled "Nucleotide State Regulates Asymmetric Substrate-Binding Protein Docking in a Type II ABC Importer" (Manuscript ID: NCOMMS-26-077690 v1.0).<p dir="ltr">Type II ABC importers rely on substrate-binding proteins (SBP) to capture nutrients and deliver them to membrane-embedded transporters, but how ATP binding and hydrolysis regulate their interactions remains poorly understood. To address these questions, we determined cryo-EM structures of the Type II small-substrate molybdate importer MolBC-A from <i>H. influenzae</i> in distinct nucl
figshare2026 · Imaging
Nanometer-resolution imaging of living bacteria across species and cellular orientations<p dir="ltr">The bacterial cell envelope is a complex superstructure that is an important target and a major barrier for antibiotics. To date, highest-resolution images of native cell envelopes have been obtained by atomic force microscopy (AFM), but its use is limited by challenges in bacterial immobilization. We establish glutaraldehyde-functionalized glass surfaces for reversible covalent attac
figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Bronchial epithelial control of <i>Aspergillus fumigatus</i> filamentation involves PI3K/laminin-332 signaling and FleA-dependent interactions with ITGB1 and MRC2<p dir="ltr">Raw data of figures 1, 2, 3, 4, 5, 6, and supplementary figures 1 and 2.</p>
ZivaHub2023 · dataset · unknown
Investigating the mechanism of action underlying the ability of kappa opioid receptor agonists to promote oligodendrocyte differentiation and myelination in vitro<p><strong>Multiple sclerosis (MS) is a demyelinating, autoimmune, neuroinflammatory disease that affects ~3 million people worldwide. In MS, the body’s immune system attacks the protective myelin coating surrounding nerve cells, impairing salutatory conduction. Unfortunately, there is no cure for MS, and due to the scarcity of effective treatment options that promote recovery, researchers look to