figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Data Sheet 1_Complement C1q promotes primary haemostasis in a microfluidic bleeding model.pdfBackground<p>In systemic inflammatory diseases, thrombotic complications often cannot be fully explained by traditional risk factors, suggesting that the immune system directly affects hemostasis. The complement system, particularly C1q (the recognition molecule of the classical complement pathway), has been shown to enhance primary hemostasis in vivo and to bind von Willebrand factor (vWF) in vit
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S7 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S7. Function of neutrophils and neutrophil-T cell interactions in CRLM.</p>
UCL Research Data Repository2026 · dataset · unknown
Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomesInflammasomes are innate immune signalling complexes vital in the activation of caspase-1, inflammation and wound healing. The dysregulation of inflammasome activity has been linked to the development of autoinflammatory diseases. Recently, the role of post-translational modifications has been identified to play an important role in regulating inflammasome activity, in particular the process of ub
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Cross-Species Profiling of Itaconate-Mediated Modifications by a Universal ProbeThe immunometabolite itaconate can covalently modify proteins through cysteine itaconation and lysine itaconylation. Current bioorthogonal itaconate probes show biased specificity for profiling cysteine itaconation in macrophages versus bacteria and are not compatible with profiling lysine itaconylation at all. Here, we report isoC3A, a universal probe designed for the comprehensive chemoproteomic
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Cross-Species Profiling of Itaconate-Mediated Modifications by a Universal ProbeThe immunometabolite itaconate can covalently modify proteins through cysteine itaconation and lysine itaconylation. Current bioorthogonal itaconate probes show biased specificity for profiling cysteine itaconation in macrophages versus bacteria and are not compatible with profiling lysine itaconylation at all. Here, we report isoC3A, a universal probe designed for the comprehensive chemoproteomic
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S6 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S6. Analysis of BHLHE40 binding and hypoxia/glycolysis signature in neutrophils from CRLM.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S8 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S8. Role of neutrophil-specific Bhlhe40 knockout in the liver orthotopic implantation mouse model.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Table S4 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Table S4. Schedule of antibodies and fluorophores Opal for mIHC.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Table S2 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Table S2. Clinicopathologic Characteristics of the patients in cohort 2, related to Figure 2.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Cross-Species Profiling of Itaconate-Mediated Modifications by a Universal ProbeThe immunometabolite itaconate can covalently modify proteins through cysteine itaconation and lysine itaconylation. Current bioorthogonal itaconate probes show biased specificity for profiling cysteine itaconation in macrophages versus bacteria and are not compatible with profiling lysine itaconylation at all. Here, we report isoC3A, a universal probe designed for the comprehensive chemoproteomic
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S1 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S1. the role of neutrophils in liver metastasis in CRLM mouse models.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S5 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S5. Single-cell analysis of neutrophil markers in peripheral blood and bone marrow.</p>
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Cross-Species Profiling of Itaconate-Mediated Modifications by a Universal ProbeThe immunometabolite itaconate can covalently modify proteins through cysteine itaconation and lysine itaconylation. Current bioorthogonal itaconate probes show biased specificity for profiling cysteine itaconation in macrophages versus bacteria and are not compatible with profiling lysine itaconylation at all. Here, we report isoC3A, a universal probe designed for the comprehensive chemoproteomic
UCL Research Data Repository2026 · dataset · unknown
Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection in infants under two years old. Sparking seasonal epidemics, RSV contributes to around 20,000 admissions to hospital in the UK annually and many require intensive care support. Peak incidences of severe RSV disease occur between 6 weeks and 6 months of age. Despite over 60 years of rese
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S3 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S3. Characterization and tissue distribution of neutrophil subsets in CRC and CRLM from public datasets.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S2 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S2. Single-cell annotation in CRLM.</p>
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset
Assessing the relationship of host immune responses and infection to recurrent pulmonary exacerbations in cystic fibrosisPulmonary exacerbations (PEx) are clinically impactful events that accelerate Cystic Fibrosis (CF) lung disease progression. Current PEx treatment approaches have suboptimal outcomes and the frequency of PEx experienced by people with CF (pwCF) is variable and poorly predicted by demographic or clinical factors. There is an unmet need to improve the prediction, treatment, and management of PEx, ho
ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue
Cross-Species Profiling of Itaconate-Mediated Modifications by a Universal ProbeThe immunometabolite itaconate can covalently modify proteins through cysteine itaconation and lysine itaconylation. Current bioorthogonal itaconate probes show biased specificity for profiling cysteine itaconation in macrophages versus bacteria and are not compatible with profiling lysine itaconylation at all. Here, we report isoC3A, a universal probe designed for the comprehensive chemoproteomic
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Table S5 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Table S5. Sequences of the primers used in real-time RT-PCR analysis.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Characterising ferritin as a danger-associated molecular pattern in inflammasome-mediated inflammation in acute respiratory distress syndromeAcute respiratory distress syndrome (ARDS) is a highly inflammatory condition with high mortality. There is evidence of inflammasome activity in ARDS patients, including NLRP3 inflammasome activation. NLRP3 activation requires two signals, termed priming and activation. The priming and activation signals can be from pathogen-associated or danger-associated molecular patterns (PAMPS and DAMPS). Act
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Figure S4 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Figure S4. Localization of TAN subsets in liver metastasis.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Table S3 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Table S3. Antibodies for IHC staining and flow cytometry.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown
Table S1 from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis<p>Table S1. Clinicopathologic Characteristics of the patients in cohort 1.</p>
ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset
Airway epithelium and respiratory syncytial virus - effect of developmental age on responses to infectionRespiratory syncytial virus (RSV) remains a significant global health concern, particularly among vulnerable populations, such as infants and older adults, who experience the greatest burden of severe disease. Despite advances in vaccine development and monoclonal antibody prophylaxis, understanding the immune determinants underlying severe RSV disease remains incomplete. The disease is primarily
ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown
Innate memory to bacterial infectionThe innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, heat killed bacterial immunisation and bacterial infection.<br><br>This study hypothesised that follow