DataCite2026 · dataset
Data from: Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seedingMutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates. Previous studies have shown that mice expressing the ALS-causing G85R variant of SOD1 develop paralysis much faster after intraspinal injection of spinal homogenates from paralyzed G85R SOD1 mice. These findings, and other studies in cell model