NCL Data2026 · dataset
TRPV1 Is Critical for Generating Immediate Apneic Response to Fentanyl<p dir="ltr">The Dataset from our study reveal that the apneic response is facilitated by systemic activation of TRPV1, but nearly blocked by antagonism of these receptors. Particularly, MORs and TRPV1 are co-expressed in vagal sensory afferents and their local interaction play a key role in generating the fentanyl-induced apnea.</p>
ZivaHub2026 · dataset
Metabolic–osmoregulatory coupling in insulin physiology: revisiting Epple and Brinn fifty years later<p dir="ltr"><b>Hypothesis and evidence-synthesis preprint, Audited v1.3.2, 28 September 2026.</b></p><p dir="ltr">This work reassesses the relationship between glucose–insulin physiology and osmotic, ionic, water-balance and cell-volume physiology, fifty years after August Epple and Jack E. Brinn proposed a broader metabolic–osmoregulatory interpretation of the pancreatic islet organ. The central
figshare2026 · Astronomical catalogue
Supplemental video S2: Arterial supply of the adult male mouse rhabdosphincter and urethra<p dir="ltr">Cleared lower abdomen and pelvis of adult C57Bl/6 male mouse perfused intracardially with a DY649 conjugate of Tomato lectin and viewed with light sheet microscopy (Ultramicroscope Blaze, Miltenyi Biotec, Germany). Segmentations of vessels (Syglass) and organs (Imaris) demonstrating the origins of the vasculature supply of the urethra and rhabdosphincter in the context of the entire p
figshare2026 · Astronomical catalogue
Supplemental video S3: Sinusoids in the lamina propria of the adult female mouse urethra<p dir="ltr">Flat mounted whole urethra and rhabdosphincter from an adult C57Bl/6 female mouse, perfused intracardially with a DY649 conjugate of Tomato lectin immunostained for vascular markers PECAM1 and PODXL and viewed with confocal microscopy (Zeiss LSM900, Carl Zeiss Microscopy). Image of the thickness of urethral wall, including the lamina propria and surrounding smooth muscle layers. Capil
figshare2026 · Astronomical catalogue
Supplemental video S1: Arterial supply of the adult female mouse rhabdosphincter and urethra<p dir="ltr">Cleared lower abdomen and pelvis of adult C57Bl/6 female mouse perfused intracardially with a DY649 conjugate of Tomato lectin and viewed with light sheet microscopy (Ultramicroscope Blaze, Miltenyi Biotec, Germany). Segmentations of vessels (Syglass) and organs (Imaris) demonstrating the origins of the vasculature supply of the urethra and rhabdosphincter in the context of the entire
figshare2026 · Astronomical catalogue
Supplemental video S4: Sinusoids in the lamina propria of the adult male mouse pelvic urethra<p dir="ltr">Cleared lower urinary tract from an adult C57Bl/6 male mouse, perfused intracardially with a DY649 conjugate of Tomato lectin immunostained for vascular markers PECAM1 and PODXL and viewed with light sheet microscopy (Ultramicroscope II, Miltenyi Biotec, Germany). Image of the junction between the pelvic urethra and penile body. In this region of the pelvic urethra, the rhabdosphincte