117 datasets

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Background<p>High-risk neuroblastoma frequently relapses after intensive therapy, but the treatment-associated malignant-neuroblast programs that inform baseline tumor risk remain incompletely defined. We used longitudinal single-cell/single-nucleus RNA-seq data to identify post-treatment transcriptional changes in malignant neuroblasts and evaluated their prognostic relevance in diagnostic bulk R

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

Background<p>Inflammatory markers have been reported to be associated with outcomes in non-small cell lung cancer (NSCLC). However, whether early treatment-related changes in these markers provide additional prognostic information remains unclear. This study evaluated the association between dynamic changes in peripheral blood inflammatory markers during chemotherapy and survival outcomes in patie

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown

<p>Detailed information on antibodies used in this study</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Background<p>High-risk neuroblastoma frequently relapses after intensive therapy, but the treatment-associated malignant-neuroblast programs that inform baseline tumor risk remain incompletely defined. We used longitudinal single-cell/single-nucleus RNA-seq data to identify post-treatment transcriptional changes in malignant neuroblasts and evaluated their prognostic relevance in diagnostic bulk R

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

<p dir="ltr">Seurat object (Filtered, processed scRNA-seq data) from Sakimoto et al, BJC Reports, 2024 (https://doi.org/10.1038/s44276-024-00112-3).</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown

<p>sCAF signature defined by marker genes of the sCAF population</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown

<p>Differentially expressed genes (DEGs) between pseudo ground-truth senescent and non-senescent CAFs that were used as input features for CSPM model training</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown

<p>Primer sequences used for qPCR</p>

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset includes THz image data collected as part of the TERABOTICS study, conducted in collaboration with the University of Warwick and University Hospitals Coventry and Warwickshire. The study aimed to test the applicability of THz imaging for <i>in vivo </i>classification of basal cell carcinoma (BCC). In total, 79 patients were measured between November 2024 and March 2026. <

figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Single-cell RNA sequencing

Background<p>High-risk neuroblastoma frequently relapses after intensive therapy, but the treatment-associated malignant-neuroblast programs that inform baseline tumor risk remain incompletely defined. We used longitudinal single-cell/single-nucleus RNA-seq data to identify post-treatment transcriptional changes in malignant neuroblasts and evaluated their prognostic relevance in diagnostic bulk R

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue · unknown

<p>Supplementary Tables file contains key information and supporting datasets. Table S1 | Clinicopathological features of the 22 MIBC patients. Table S2 | The top 50 most significantly differentially expressed genes between the 15 single cell clusters. Table S3 | GSEA pathway enrichment results for 4 spatial clusters. Table S4 | Clinical characteristics and spatial tumor state composition across s

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

Introduction: <br>Five-year survival rates for oesophageal adenocarcinoma (OAC) remain poor at approximately 15%. The development of drug-resistance limits the effectiveness of current chemotherapies, with less than 20% of patients experiencing complete pathological response, so the discovery of underlying resistance mechanisms and novel agents to target these pathways is crucial.<br><br>Materials

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Targeting tumour microenvironment (TME) is an emerging strategy to fight cancer. In TME, cancer cells exhibit abnormal vasculature and altered metabolic states (anaerobic respiration instead of aerobic respiration) to cope with their high oxygen and nutrient demands. Remoulding TME via normalizing vasculature and preventing lactic acid transport contributes to the inhibition of tumour development.

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring chemosensitivity was assessed via a number of methods, including RNAi, CRISPR, and targeted inhibition. In all, the

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Our group previously identified a subgroup of oesophageal adenocarcinoma (OAC) patients with DNA repair deficiency who show improved responses to neoadjuvant chemotherapy using the DNA Damage Immune Response (DDIR) gene expression signature. DDIR positivity is associated with an inflamed tumour microenvironment, including increased lymphocyte infiltration and immune checkpoint expression, features

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · restricted

Breast cancer susceptibility gene 1 (BRCA1) plays an essential role in repairing DNA damages. Inherited BRCA1 mutation is linked to higher risks of breast and ovarian cancer, meaning the mutation carriers are likely to require cancer treatments. This thesis uses a special mouse model carrying an oocyte(egg)-specific BRCA1 mutation to exam the impact of cancer treatment on female’s ovarian health.

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown

<p>Supplementary Methods file contains extended methods, including the processing and analysis of multiple sequencing datasets.</p>

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

Prostate cancer (PC) is the second most common type of cancer in men worldwide. A range of effective anti-cancer drugs have been used to treat advanced PC however, their systemic toxicity has limited their clinical use. Therefore, there is an unmet need to develop novel selective drug delivery strategies to deliver cancer therapeutics to PC tissues. Two most common selective targeting approaches t

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown

<p>Supplementary Figures file contains Supplementary Figures S1–S15. Figure S1 | Pathology-guided spatial annotation across 22 MIBC tumors. Figure S2 | Validation of spatial deconvolution accuracy and cell-type compartmentalization. Figure S3 | Additional tumors demonstrating spatial CNV-based subclones and transcriptional divergence. Figure S4 | Cross-platform concordance of CNV profiles inferred

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the UK and remains a major global health burden. Although precision medicine and targeted therapies have advanced, many CRC patients still depend on standard 5-Fluorouracil (5-FU)-based chemotherapy, which lacks reliable biomarkers for predicting treatment response. The transcription factor p53 plays a key role in CRC

DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

Background:Lower treatment rates in older patients with cancer exist but may reflect contraindications of advanced disease, comorbidities and frailty. This thesis aimed to firstly review the evidence for under-treatment (UT), secondly to assess the potential for UT using patient-level cancer registry data and secondary population-based statistics, finally to compile a dataset and develop a method

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">Stem cells and related research and therapy.</p><p dir="ltr"><br></p>

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">GastricUS-Seg contains 616 transabdominal B-mode ultrasound images from 104 patients with pathologically confirmed primary gastric cancer, acquired after oral contrast filling of the stomach at a single tertiary hospital in China and organised into eight anonymised acquisition groups (A–H). Every image is paired with a binary pixel-level lesion mask (PNG, 255 = lesion, 0 = background)

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset contains the raw data associated with Figure 5D of the manuscript.</p>

ZivaHub + HKU DataHub + DaYta Ya Rona + figshare + Loughborough Research Repository + UP Research Data Repository2026 · RNA sequencing

<p dir="ltr"><a href="https://figshare.com/account/articles/30597953" target="_blank">Differentially expressed genes in response to BN-treatment</a></p>