NCBI GEO2026 · RNA sequencing · 90 samples
Single-cell multiomic integration identifies widespread, cell-type resolved fetal reactivation in the diseased human heart…Results: We generate an integrated multiomic atlas of human cardiac cells, combining newly generated and publicly available single-nucleus RNA sequencing datasets from 299 donors and… …single nucleus ATAC-seq datasets from 106 donors.…
NCBI GEO2026 · RNA sequencing · 19 samples
Single Nucleus RNA sequencing Identifies PLXNA4 Upregulation in End Stage Arrhythmogenic Right Ventricular Cardiomyopathy…We carried out single-nucleus RNA sequencing (snRNA-seq) on 11 non-failing and 8 ARVC patient right ventricular samples and transcriptionally profiled 139,347 nuclei.… …We identified over 4,400 differentially expressed protein coding genes between non-failing and ARVC samples across cell types.…
NCBI GEO2026 · Image data · 9 samples
Application of spatial transcriptomics across organoids for a high-resolution spatial whole-transcriptome benchmarking dataset…Stem cell-derived organoids hold promise to model tissue-specific disease.… …This study presents the first systematic profiling of multiple stem cell derived organoid models (brain, heart muscle, heart valve, kidney, lung, cartilage, and haematopoietic) with…