NCBI GEO2026 · RNA sequencing · 14 samples
Transcriptomic analysis of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using scRNAseq…We performed single cell RNAseq on whole hearts from E13.5 Dp1Tyb embryos and from wild-type littermates.…
NCBI GEO2026 · Image data · 9 samples
Application of spatial transcriptomics across organoids for a high-resolution spatial whole-transcriptome benchmarking dataset…Stem cell-derived organoids hold promise to model tissue-specific disease.… …This study presents the first systematic profiling of multiple stem cell derived organoid models (brain, heart muscle, heart valve, kidney, lung, cartilage, and haematopoietic) with…
NCBI GEO2026 · Image data · 1 samples
Lineage and Organ Signals Sequentially Build Organ Intrinsic Nervous Systems [Spatial Transcriptomics]…Despite their importance, how these distinct neural architectures arise from a common neural crest cell (NCC) origin has remained unclear.… …Here, we present a systems-level, cross-organ analysis of OINS development, integrating lineage tracing, 3D imaging, single-cell transcriptomics, and genetic perturbations across heart…
NCBI GEO2026 · Archive · 2 samples
Transient Senescence Following Myocardial Infarction: Characterization and Functional Implications in Cardiac Remodeling [SpatialTranscriptome]…However, the characteristics and functions of the senescent cells (Sen.) following MI-induced cardiac remodeling remains elusive.… …Then we analyzed our single-nucleus (sn)-multiome and fluorescence-based (SPiDER-β-gal/p16-EGFP) spatial transcriptomics data from the infarcted heart on day 7 post-MI to identify the…