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}NCBI GEO2026 · RNA sequencing · 12 samples
Mast cell St8sia1-GD3 axis as a glyco-epigenetic checkpoint driving maladaptive cardiac remodeling [RNA-seq]…Pathogenical immune-cardiac crosstalk underlies maladaptive remodeling in chronic heart failure, yet therapies directly targeting this axis are lacking.… …We performed integrative analyses of bulk and single-cell RNA sequencing data from failing human and mouse hearts.…
NCBI GEO2026 · RNA sequencing · 6 samples
Identification of Biomarkers in Myocardial Hypertrophy and Fibrosis via Integrated Transcriptomic and Phosphoproteomic Profiling…These processes contribute to heart failure and sudden death, yet their molecular mechanisms remain unclear.… …These data were integrated with public single-cell RNA sequencing datasets.…
NCBI GEO2026 · RNA sequencing · 9 samples
Genome-wide association mapping for cardiomyocyte ploidy identifies Shroom3 as responsible for hyperpolyploidy and ventricular dilation [bulkRNA-Seq]…Furthermore, functional characterization of single nucleotide variants resulting in amino acid changes within SHROOM3 confirmed two protein coding variants that disrupted SHROOM3-ACTIN… …interaction and led to altered expression of cell cycle genes.…