Omics · study · 2026
Transcriptomic Profiling of Neonatal Offspring Hearts from Gestational Diabetes Mellitus Rat Models
Listed in NCBI GEO
Maternal diabetes during pregnancy has been associated with an increased risk of metabolic and cardiovascular disorders in the offspring.
Description
However, the underlying mechanisms by which intrauterine hyperglycemia impairs fetal cardiovascular development remain incompletely understood. Our study aimed to characterize the intrauterine environment in the setting of maternal diabetes mellitus and to identify the associated molecular alterations in the fetal heart.
A rat model of intrauterine hyperglycemia was established to investigate transcriptomic changes in the cardiac tissue of offspring.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298866 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298866 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1271523 ncbi.nlm.nih.gov/bioproject/PRJNA1271523 ↗
project · from NCBI GEO
- PubMed 42552314 pubmed.ncbi.nlm.nih.gov/42552314 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- Heart 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298866 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |