Data · dataset · 2024
Phase II study of oral metformin for intravesical treatment of non- muscle-invasive bladder cancer
Listed in IISH Dataverse
Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract, with ~3,700 new cases and a prevalence of ~32,000 patients in the Netherlands in 2016.
Description
Despite current treatments, it is associated with high risk of recurrence and/or progression. Metformin is effective against bladder cancer in animal models.
The objective of this multicenter, open-label, phase 2 study is to determine the complete response rate of bladder cancer to administration of oral metformin for 3 months in ablating a marker tumour deliberately left following transurethral resection of multiple, papillary tumours in the bladder. Secondary outcomes are the partial response rate, overal saftety of metformin and the duration of time to recurrence after marker lesion resection.
Links
Where it is published
- Dataverse dataset page dataverse.nl/dataset.xhtml?persistentId=doi%3A10.34894%2FB5OD0M ↗
landing page · from datasets iisg amsterdam
- DOI doi.org/10.34894/b5od0m ↗
DOI / persistent id · from datasets iisg amsterdam
Catalogue records · 1
- Dataverse API dataverse.nl/api/datasets/:persistentId/?persistentId=doi%3A10.34894%2FB5OD… ↗
metadata API · from datasets iisg amsterdam
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Life Sciences · Medicine & Health
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| IISH Dataverse | doi:10.34894/B5OD0M | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · datasets iisg amsterdam | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /subjects |
| created_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| description | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /description |
| publication_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| title | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | /name |
| updated_date | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 | |
| version_label | source · datasets iisg amsterdam | connector:datasets_iisg_amsterdam@1.0.0 |