Higher Interleukin 13 differentiates patients with a positive history of suicide attempts in major depressive disorder

Neuroinflammation has been reported in neuropsychiatricconditions, including major depressive disorder (MDD). Preliminary findings suggested a link between inflammation and suicidal behavior.

Nevertheless,to the best of our knowledge, no previous study explored how a wide range of cytokines may differentiate lifetime suicidal behaviors (i.e. positive history of suicide attempts) in patients affected by MDD. In 28 healthy controls (HC), 28 MDD patients with a positive history of attempting suicide (SA), and 28 MDD patients with a negative history (nSA), we determined concentrations of immune analytes using an ultra-sensitive Pro Human Cytokine Group 27-Plex Panel and Chemokine immunoassay panels (Bioplex).