Data · dataset · 2025
KIF1C activates and extends dynein movement through the FHF cargo adaptor
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1038/s41594-024-01418-z
Cellular cargos move bidirectionally on microtubules by recruiting opposite polarity motors dynein and kinesin.
Description
These motors show co-dependence, where one requires the activity of the other, although the mechanism is unknown. Here, using in vitro reconstitutions, we show the kinesin-3 KIF1C acts both as an activator and processivity factor for dynein.
Activation requires only a fragment of the non-motor tail of KIF1C (KIF1C-stalk) binding the cargo adaptor HOOK3. The interaction site is separate from the constitutive factors FTS and FHIP, which link HOOK3 to small G-proteins on cargos. We provide a structural model for the auto-inhibited FTS- HOOK3-FHIP1B (FHF) and explain how KIF1C relieves it.
Read the rest (1 more)
Collectively, we explain co-dependency by revealing how mutual activation of dynein and kinesin occurs through their shared adaptor. Many adaptors bind both dynein and kinesins, suggesting this mechanism could be generalised to other bidirectional complexes.
Links
Where it is published
- DOI doi.org/10.1038/s41594-024-01418-z ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences
- Inferred from text
- Biochemistry and cell biology 69%
Provenance · 3 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34047156 | 9 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34047156 | 9 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34047156 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |