Table 1_Triglyceride–glucose index and structural chromosome aberrations in medical radiation workers: a cross-sectional study with a stratified dosimetry substudy.docx

Compared with the lowest TyG quartile, the adjusted IRR was 1.52 (95% CI, 1.27–1.83) for the highest quartile (P for trend < 0.001). Restricted cubic spline analysis suggested a non-linear pattern, with a steeper estimated association at higher TyG values (P for non-linearity = 0.013). In the dosimetry substudy, the adjusted IRR was 1.27 (95% CI, 1.14–1.42) per 1-SD increase after adjustment for recorded cumulative occupational dose and other covariates; the inverse-probability-weighted estimate was similar (IRR, 1.25; 95% CI, 1.11–1.41).

Recorded cumulative occupational dose was also positively associated with structural chromosome aberration count after additional adjustment for TyG (adjusted IRR per 10-mSv increase, 1.10; 95% CI, 1.04–1.17).</p>Conclusions<p>Higher TyG was associated with a greater structural chromosome aberration count among medical radiation workers, including after adjustment for recorded cumulative occupational dose. The cross-sectional design, incomplete exposure characterization, and potential residual confounding preclude causal interpretation or use of TyG for individual occupational risk stratification.</p>