Data from: In-vivo analysis of medial perforant path-evoked excitation and inhibition in dentate granule cells

The hippocampal dentate gyrus is a brain area thought to be strongly regulated by inhibition. In vivo, it exhibits remarkably sparse activity, a characteristic proposed to underlie computational tasks like pattern separation.

Several populations of interneurons mediate strong feedforward as well as feedback inhibition onto granule cells. However, the dynamics of inhibition control granule cell activity in vivo are insufficiently studied. Using two-photon in vivo Ca2+ imaging in mice of either sex, we show that sensory stimulation activates only a small number of dentate gyrus granule cells, while inducing widespread inhibition across the remaining granule cell population.