Regulatory Mechanisms of Neuro-immune Interaction in the Skin-Brain Axis on Acupuncture Intervention in the Itch Circuitry of Psychodermatological Disorders

The vicious cycle of "itch-scratch-emotion" severely impairs patients' health. Its pathological essence lies in the neuro-immune homeostatic imbalance and central network dysfunction regulated by the "skin-brain axis".

Current mechanistic studies predominantly focus on downstream chemical sensory pathways, often overlooking the critical role of mechanical itch sensitization driven by tissue biomechanical remodeling. Acupuncture, a classic exogenous mechanical neuromodulation technique, not only induces the desensitization of peripheral mechanosensitive ion channels to block inflammatory cascades but also "bottom-up" reshapes the central itch-emotion brain network and autonomic nervous function, systematically restoring skin microenvironment homeostasis.