Table · dataset · 2026
Inflammation-Responsive Transthyretin Links Neuroimmune Adaptation to Cognitive Resilience During Aging
Listed in HKU DataHub and figshare and Loughborough Research Repository — shown once because both records carry DOI 10.6084/m9.figshare.34003692.v1
<p dir="ltr">The brain must adapt to peripheral inflammatory stress while preserving neurovascular and cognitive function, but the endogenous mechanisms that coordinate this response remain incompletely understood.
Description
Here, we investigated transthyretin (TTR) as an inflammation-responsive component of hippocampal neuroimmune adaptation and examined how this response changes with persistent microbial stress and aging. During acute intestinal inflammation, hippocampal TTR induction closely paralleled microglial inflammatory activation.
In vitro, bacterial outer membrane vesicles (OMV) induced inflammatory cytokine expression and increased TTR protein in neurovascular cells, while TNF-α directly induced TTR in microglia and brain endothelial cells. Hippocampal TTR overexpression elicited transcriptional programs enriched for innate immune sensing, host defense, antigen processing, and chemokine signaling, indicating that TTR can actively shape the local immune response.
Read the rest (2 more)
In contrast to the inducible response observed during acute challenge, chronic OMV exposure reduced hippocampal TTR and increased blood-brain barrier (BBB) permeability. Aging was likewise associated with lower hippocampal TTR and loss of the dynamic TTR and BBB responses to intestinal inflammation. Functionally, sustained hippocampal TTR supplementation improved spatial working memory in aged mice, with a trend toward improved recognition memory.
Together, these findings identify TTR as an inflammation-responsive regulator of hippocampal immune adaptation whose inducibility is attenuated by persistent microbial stress and aging. This loss of adaptive TTR responsiveness may contribute to declining neurovascular and cognitive resilience with age.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34003692.v1 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Zoology 69%
Provenance · 3 source records, 32 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/34003692 | 9 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34003692 | 9 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34003692 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].anzsrc:group:3109 | enrichment · datahub hku hk | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |