Omics · study · 2026
RNA-seq analysis of Caenorhabditis elegans treated with Lycii Fructus polysaccharide (FSP)
Listed in NCBI GEO
Description
Lycii Fructus polysaccharides are widely reported to possess anti-aging and cytoprotective properties, but the molecular mechanisms underlying their effects on mitochondrial homeostasis remain unclear.RNA sequencing was performed to investigate transcriptomic changes in Caenorhabditis elegans treated with a purified Lycii Fructus polysaccharide fraction (FSP). Differential expression and pathway enrichment analyses revealed significant activation of mitochondrial unfolded protein response (UPRmt) and longevity-associated pathways, suggesting that FSP promotes mitochondrial homeostasis and stress resilience during aging.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324598 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324598 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1435922 ncbi.nlm.nih.gov/bioproject/PRJNA1435922 ↗
project · from NCBI GEO
- PubMed 42650207 pubmed.ncbi.nlm.nih.gov/42650207 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Caenorhabditis elegans · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324598 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:6239 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |