Data Sheet 1_Daily consumption of sulfate- and magnesium-rich mineral water enhances bowel function in adults with chronic constipation: a randomized double-blind real-world trial.docx

Secondary outcomes included stool consistency, responder rates, time to treatment response, constipation-related symptoms (PAC-SYM), constipation-related quality of life (PAC-QoL), gastrointestinal transit time, laxative use, and safety.</p>Results<p>After 2 weeks (additional analysis), bowel movement frequency increased significantly more in the HSM group than in the control group (mean change: 1.31 ± 3.24 vs. 0.34 ± 2.49 bowel movements/week; p = 0.043).

This effect was more pronounced in participants with moderate-to-severe constipation (p = 0.022). No significant between-group difference was observed at the end of week 3 (p = 0.144). Time to treatment response was significantly shorter with HSM water than with control water (median 9 vs. 16 days; p = 0.042), accompanied by a higher responder rate in participants with moderate-to-severe constipation (p = 0.043).

No significant between-group differences were observed for stool consistency, constipation symptoms, quality of life, or gastrointestinal transit time. Both interventions were well tolerated, and only mild transient adverse events were reported.</p>Discussion<p>Daily consumption of 1 L of sulfate- and magnesium-rich mineral water, combined with adequate hydration, improved bowel movement frequency at week two and accelerated treatment response in adults with chronic constipation, whereas the between-group difference at the registered primary endpoint (week three) was not statistically significant.

These findings suggest that sulfate- and magnesium-rich mineral water may serve as a safe, non-pharmacological dietary approach for the management of chronic constipation under real-world conditions.</p>Clinical trial registration<p>clinicaltrials.gov/, DRKS00034871.</p>