Omics · study · 2026
MOS4-Associated Complex subunits 3A and 3B modulate FLM splicing to repress floral transition in short day
Listed in NCBI GEO
Flowering initiation is a crucial and complex process tightly regulated at the molecular level.
Description
Alternative splicing introduces transcript variability under different environments. MAC3A and MAC3B, components of the MOS4-associated Complex (MAC) in Arabidopsis, play pivotal roles in this process.
This study investigates the intricate role of MAC3A and MAC3B in shaping the flowering cascade via alternative splicing. Previous observations on the flowering phenotype of mac3a/mac3b knockdown mutants highlight the negative role of MAC3A and MAC3B on flowering initiation specifically under short-day conditions, but the mechanism remains unknown. To explore the underlying reason, We perform RNA-seq analysis, which reveals extensive splicing defects in flowering initiation pathways, indicating the broad influence of MAC3A and MAC3B on flowering induction.
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Moreover, mac3a/mac3b mutants exhibit the early flowering trait, most possibly because of the deficient FLOWERING LOCUS C (FLC) expression and the abnormal splicing patterns FLOWERING LOCUS M (FLM), namely the lower ratio between cool-temperature-induced FLM- to warm-temperature-induced FLM- , under short days.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261591 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261591 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1078069 ncbi.nlm.nih.gov/bioproject/PRJNA1078069 ↗
project · from NCBI GEO
Topics
- Stated by source
- Arabidopsis thaliana · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Genetics 70% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE261591 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:3702 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |