Divergent virulence and serological profiles reveal pathogenic evolution within the Bandavirus genus

These data were used to construct the maximum-likelihood phylogenetic trees (Fig 1A-D) and generate the conservation plots (Fig 1E).Fig 2.xlsx & Fig 2.rar: Cell tropism and replication kinetics data for five bandaviruses across 10 mammalian cell lines.

The Excel file contains triplicate TCID₅₀ titers from one-step growth curves (0-96 hpi). The archive includes unprocessed immunofluorescence images (Fig 2A) and additional bright-field/merged images confirming no cytopathic effect in Vero cells (Fig S2).Fig 3.xlsx: Longitudinal infection dynamics and immune response data in C57BL/6 mice, including body weight, serum viral loads, virus-specific IgM/IgG titers, and cross-neutralization assay results used to generate the antigenic heatmap (Fig 3E).Fig 4.xlsx: Virulence and hematological data in IFNAR⁻/⁻ mice, including survival rates across serial viral doses (10⁻² to 10⁷ TCID₅₀) and complete blood count/liver enzyme measurements at 3 dpi.Fig 5.xlsx & Fig 5.rar: Organ-specific pathology and viral distribution data.