Data · dataset · 2014
Defects in the Acquisition of Tumor-Killing Capability of CD8+ Cytotoxic T Cells in Streptozotocin-induced Diabetic Mice
Listed in DataCite
Diabetes mellitus has been known not only to associate with an increased risk of cancers but also heighten the mortality rate.
Description
However, whether the antitumor CD8+ T cell immunity is down-modulated in diabetic hosts remains not clear. Our data depicts that, even harboring intact proliferative capacity, streptozotocin-induced diabetic (STZ-diabetic) CD8+ T cells produce less perforin and TNFa and express less CD103 protein after stimulation.
In advance, adoptive transfer of STZ-diabetic P14 CD8+ T effector cells show insufficient infiltration to B16.gp33 melanoma in vivo and inadequate production of perforin, granzyme B and TNFa in the tumor. STZ-diabetic CD8+ CTLs are neither able to eliminate tumor nor improve survival of tumor-bearing mice. In conclusion, diabetic CD8+ CTLs are crippled to infiltrate into tumors and fail to acquire tumor-killing capability.
Read the rest (1 more)
These new findings will have major impact on elucidating how diabetic CD8+ T cells are dysregulated and impeded by the acquisition of full effector functions and tumor-killing capability. With such exciting findings, we believe that our study will advance strategies of inducing protective antitumor immunity in diabetic hosts.
Links
Where it is published
- Repository landing page figshare.com/articles/dataset/Defects_in_the_Acquisition_of_Tumor_Killing_C… ↗
landing page · from DataCite
- Repository landing page figshare.com/articles/dataset/Defects_in_the_Acquisition_of_Tumor_Killing_C… ↗
landing page · from DataCite
- DOI doi.org/10.6084/m9.figshare.1170000 ↗
DOI / persistent id · from DataCite
- DOI doi.org/10.6084/m9.figshare.1170000.v1 ↗
DOI / persistent id · from DataCite
Documentation and papers
Catalogue records · 4
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1170000.v1 ↗
metadata API · from DataCite
- DataCite API api.datacite.org/dois/10.6084/m9.figshare.1170000 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1170000.v1 ↗
catalogue entry · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.6084/m9.figshare.1170000 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Clinical medicine · Clinical medicine
- From keywords
- Cancer · Cancer · Immunology · Medicine & Health · Medicine & Health
Provenance · 2 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.1170000 | 15 d ago | JSON v1 |
| DataCite | 10.6084/m9.figshare.1170000.v1 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:clinical-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| concepts[field].local:field:medicine-health | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['Medicine'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |