Omics · study · 2026
Silver ions and nanoparticles elicit distinct patterns of stress compartmentalization in Pseudomonas aeruginosa
Listed in NCBI GEO
Silver nanoparticles (AgNPs) and dissolved silver ions (Ag(aq)) both exhibit antimicrobial activity, yet the subcellular mechanisms by which bacteria respond to each form remain poorly characterized.
Description
Using whole-transcriptome analysis of sublethal silver exposures under controlled water chemistry conditions, we compared the effects of intact AgNPs (i.e., not prone to substantial bulk shedding of Ag(aq)) to Ag(aq) on Pseudomonas aeruginosa.
The results show that AgNP stress is primarily exerted in the bacterial periplasm, while Ag(aq) stress is primarily exerted intracellularly. Thus, AgNPs and Ag(aq) elicit distinct, spatially segregated stress response programs in P. aeruginosa.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339228 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339228 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1498006 ncbi.nlm.nih.gov/bioproject/PRJNA1498006 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE339228 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |