Omics · study · 2026
Curcumin carbon dots promote osteogenic differentiation and exhibit antibacterial activity for peri-implantitis prevention
Listed in NCBI GEO
Peri-implantitis prevention remains a significant challenge in implant dentistry.
Description
This study evaluated the dual functionality of a curcumin-carbon dot (Cur-CD) complex in enhancing the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and exerting antibacterial effects. Primary rBMSCs were isolated and divided into control and Cur-CD-treated groups.
After 21 days of osteogenic induction, total RNA was extracted for transcriptome sequencing analysis to investigate the molecular mechanisms underlying Cur-CD-promoted osteogenesis. The results demonstrated that Cur-CD significantly enhanced mineralized nodule formation and up-regulated expression of key osteogenic markers (Runx2, OPN, Osterix, OCN), providing evidence for its potential as a bioactive agent for preventing peri-implantitis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343587 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343587 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1511914 ncbi.nlm.nih.gov/bioproject/PRJNA1511914 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343587 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |