Data Sheet 1_Structural and dynamic functional controllability: shared variance between network control metrics limits attribution to distinct domains of intelligence.docx

Controllability is typically measured for the structural connectome, but dynamic functional connectivity may better capture temporally varying processes relevant to cognition.</p>Methods<p>Using data from the Human Connectome Project, we compared the prediction of crystallized and fluid intelligence from controllability metrics measured in both structural and dynamic functional connectivity.

We hypothesized dynamic functional connectivity would outperform structural connectivity, and modal and average controllability would differentially predict fluid and crystallized intelligence.</p>Results<p>As expected, dynamic functional connectivity outperformed structural connectivity in predicting cognitive performance. However, modal and average controllability displayed similar predictive power for fluid and crystalized intelligence, and performed comparably to regional (or node) strength, a simpler graph metric reflecting the strength of immediate regional connections that strongly covaries with both controllability measures.