The retinal microvasculature as an early indicator of chronic disease risk in older populations

This easy, non-invasive imaging modality provides an indication of microvascular health that may reflect ongoing changes elsewhere in the body. The current published literature provides conflicting evidence on the associations between chronic disease and retinal microvascular parameters and this thesis provides additional support for the potential of these measures in the assessment of chronic disease outcomes.

The primary aims of this thesis were to perform cross-sectional analyses of the baseline data from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), to investigate associations between variation in retinal microvascular parameters and several chronic disease outcomes including chronic kidney disease, mild cognitive impairment, depression and diabetes. In addition, the potential systemic effects of vascular endothelial growth factor inhibition therapy, a primary intervention for the treatment of diabetic macular oedema and neovascular age-related macular degeneration, on long-term renal outcomes was evaluated in a cohort with diabetic macular oedema. <br><br>There was no evidence detected to suggest that regular long-term intravitreal vascular endothelial growth factor inhibition significantly effects renal function following treatment for diabetic macular oedema.