Excel · study · 2026
Ischemic stroke/reperfusion mRNA-seq of brain and lung tissues at different time points
Listed in NCBI GEO
Ischemic stroke can trigger secondary pulmonary complications, which severely affect clinical outcomes, but the underlying dynamic pathophysiological mechanisms remain incompletely understood.
Description
Through RNA sequencing combined with temporal transcriptomic analysis of brain/lung tissues from rat models of middle cerebral artery occlusion (MCAO, 0-2 hours) and reperfusion (12h, 1d, 3d, 5d) to explore signaling mechanisms, we discovered biphasic pulmonary pathology.
This process initiates with acute interleukin-1β (IL-1β)-mediated inflammation, progressing to sustained metabolic-inflammatory cascades governed by hypoxia-inducible factor 3α (HIF-3α) and ATP-binding cassette sub-family A member 6 (ABCA6). Integration revealed Forkhead Box O1 (FOXO1) as the hierarchical regulator orchestrating these pathological transitions.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297583 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297583 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1265213 ncbi.nlm.nih.gov/bioproject/PRJNA1265213 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297583 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |