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Data · dataset · 2026

Supplementary Material for Unger-Wallace et al., 2026

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<p dir="ltr">Unger-Wallace and co-workers found that alleles of the maize <i>p1 </i>gene for kernel color containing <i>Ac/fAc </i>transposable elements flanking a <i>p1 </i>transcriptional enhancer can induce paramutation, a type of epigenetic silencing.

Description

The authors identified DNA circle junctions derived from eccDNA (extrachromosomal circular DNA) produced by aberrant transposition reactions, and they propose that these eccDNA trigger paramutation.

On the basis of these findings, the authors propose that <i>Ac/fAc </i>transposition reactions generate eccDNA containing the <i>p1 </i>enhancer, and that transcription of the enhancer-containing eccDNA leads to sRNA accumulation and cytosine methylation of homologous sequences in the <i>p1 </i>gene, triggering <i>p1 </i>paramutation. This novel hypothesis suggests that eccDNA produced by aberrant transposition reactions can have significant impacts on gene expression.</p>

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Agricultural biotechnology 74%
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ZivaHuboai:figshare.com:article/3328960512 d agoJSON v1
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