Data · dataset · 2026
Actinium-225, prostate specific membrane antigen (PSMA), and poly(lactic-co-glycolic acid) (PLGA) nanoparticles for targeted alpha therapy of prostate cancer
Listed in UP Research Data Repository
<p dir="ltr">The purpose of this research was to develop a 225Ac-targeted alpha therapy delivery vehicle using PLGA-chitosan-folic acid-based nanoparticles for tumour selectivity. 8 to 10 MBq of 225Ac-PSMA617-TFA radiopharmaceuticals were produced.
Description
The quality controls were monitored, the radiochemical purity was determined in triplicate using a cut-and-count method, where the segments of the iTLC TSA strips were counted<br>in a gamma well counter in the Francium-221 (221Fr) energy window, 218 keV.
The data set includes tables and summaries of the research conducted. This was a prospective quantitative experimental study that included the following experiments:</p><ul><li>Radiolabeling of 225Ac PSMA</li><li>Preparation of PLGA nanoparticles</li><li>Functionalising of PLGA nanoparticles with chitosan and folic acid</li><li>Encapsulation of 225Ac PSMA into PLGA-chitosan-folic acid nanoparticles</li><li>In-vitro drug release</li></ul><p><br></p>
Links
Where it is published
- DOI doi.org/10.25403/upresearchdata.32006382.v1 ↗
DOI / persistent id · from researchdata up ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from researchdata up ac za
Topics
- From keywords
- Earth & Environmental Science · Medicine & Health
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| UP Research Data Repository | oai:figshare.com:article/32006382 | 15 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · researchdata up ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| description | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/description |
| license | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| title | source · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | /metadata/dc/title |