Evolutionary origin of Group 3/4 medulloblastoma

This repository contains variant calls from bulk whole genome sequencing of medulloblastomas that were first published in Northcott, P. A. et al. The whole-genome landscape of medulloblastoma subtypes. Nature 547, 311-317 (2017); doi.org/10.1038/nature22973 and re-analyzed for reconstructing evolutionary dynamics driving medulloblastoma initiation in the manuscript Key oncogenic event are late-stage drivers of medulloblastoma evolution and progression Konstantin Okonechnikov1,2,3*, Piyush Joshi1,2,3,4*, Verena Körber5,6*, et al. 1.

Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany 2. National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany 3. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 4.