Table · dataset · 2026
Table1_Long Non-Coding RNA NR-133666 Promotes the Proliferation and Migration of Fibroblast-Like Synoviocytes Through Regulating the miR-133c/MAPK1 Axis.DOCX
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fphar.2022.887330.s001
<p>Long non-coding RNA (lncRNA) is involved in the regulation of rheumatoid arthritis (RA) and many other diseases.
Description
In this study, a new lncRNA, NR-133666, was identified to be highly expressed in the adjuvant-induced arthritis rat model using the Agilent lncRNA microarray assay. qRT-PCR verified that NR-133666 was upregulated in fibroblast-like synoviocyte of a collagen-induced arthritis (CIA) rat model. Fluorescence in situ hybridization analysis showed that NR-133666 is mainly expressed in the cytoplasm of collagen-induced arthritis FLS.
MTT assay and EdU staining results showed that the proliferation of CIA FLS was inhibited after NR-133666 was knocked down, and the wound healing assay showed that the migration of CIA FLS was also suppressed. Dual luciferase detection was used to confirm the relationship among NR-133666, miR-133c and MAPK1. MAPK1 is the target gene of miR-133c, where NR-133666 acts as a sponge of miR-133c to reduce the inhibitory effect of miR-133c on MAPK1.
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Overexpression of NR-133666 and MAPK1 can promote the proliferation and migration of CIA FLS, and overexpression of miR-133c can reverse this phenomenon. Western blot indicated that it may be related to the ERK/MAPK signaling pathway. Collectively, we identified that lncRNA NR-133666 acted as a miR-133c sponge that can promote the proliferation and migration of CIA FLS through regulating the miR-133c/MAPK1 axis.</p>
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Where it is published
- DOI doi.org/10.3389/fphar.2022.887330.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
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Provenance · 2 source records, 36 field assertions
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|---|---|---|---|
| figshare | oai:figshare.com:article/33972829 | 5 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33972829 | 5 d ago | JSON v1 |
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|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
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| concepts[field].anzsrc:field:321401 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Basic Pharmacology'] |
| concepts[field].anzsrc:field:321402 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Clinical Pharmacology and Therapeutics'] |
| concepts[field].anzsrc:field:321402 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical Pharmacology and Therapeutics'] |
| concepts[field].anzsrc:field:321403 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical Pharmacy and Pharmacy Practice'] |
| concepts[field].anzsrc:field:321403 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Clinical Pharmacy and Pharmacy Practice'] |
| concepts[field].anzsrc:field:321406 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Pharmacogenomics'] |
| concepts[field].anzsrc:field:321406 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Pharmacogenomics'] |
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| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
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| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |