Data · dataset · 2026
<p><i>Francisella</i> MHC-II antigens and their relationship to the proteome.</p>
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<p>(A) COG annotation of <i>Francisella</i> LVS proteins entering the MHC class II pathway.
Description
Proteins associated with translation, cell wall, and lipid metabolism have emerged as important categories of proteins for antigen presentation. (B) Proteome analysis of <i>in vitro</i> cultured <i>Francisella</i> LVS.
The 1,131 proteins identified at 1% FDR were ranked by their intensity (1,129 quantifiable) to express their relative abundance in the proteome. Most MHC-II antigens (squares) were highly expressed proteins. (C) A violin plot showing the intensity distribution for a group of 1,129 LVS proteins or 23 MHC-II proteins.
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The difference between the two groups was statistically significant (two-tailed Mann-Whitney test). The median, 25th, and 75th percentiles are shown. (D) Relative quantification of proteome changes induced by deletion of the <i>dsbA</i> gene in <i>Francisella</i> LVS.
The ratios of mutant and wild-type proteins (n = 1,129) were plotted against the intensities of wild-type proteins. The localization of MHC-II proteins (squares) near the line indicating equal expression in both strains confirmed their unchanged availability for antigen presentation. In the otherwise unchanged LVSΔdsbA proteome, only a few proteins with altered expression were detected (diamonds).
Proteins of interest are indicated by FTL numbers or gene names in all figures.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.ppat.1014597.g002 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Cancer · Earth & Environmental Science · Immunology · Infectious diseases · Life Sciences · Medicine & Health · Microbiology
Provenance · 1 source records, 13 field assertions
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|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34026922 | 11 d ago | JSON v1 |
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| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |