Applications of functional materials in the analysis of aqueous samples

Combination of both research streams allowed an iterative design approach to be undertaken. Successful candidate polymers were in some cases capable of eliciting improvements in qPCR intensity as high as 300%, and scale-up of these polymers synthesis was undertaken.<br><br>In chapter 2, a combined MISPE-SERS (molecular imprinted solid phase extraction – surface enhanced Raman scattering) method for the selective detection of a range of carboxylate containing compounds is designed and evaluated.

This chapter outlines methods used for:<br>• validating interactions between functional monomers and analytical targets.<br>• polymer synthesis, characterization, and performance validation.<br>• Colloidal nanoparticle aggregation, nanoparticle self-assembly and SERS <br>detection.<br>• SPE method development and terminal detection using SERS. <br>This work in this chapter allowed for completion of a MISPE-SERS detection method for benzoic acid and partial completion of a MISPE-SERS detection method for 2,4-dichlorophenoxy acetic acid, using a dummy imprinting approach.<br><br>In chapter 3, a new method for the ‘stamping’ of a monolayer of metal nanoparticles into a robust polypropylene backbone to produce surface exposed nanosheets of greater chemical, physical and thermal robustness is outlined. <br><br><i>Thesis is embargoed until 31st December 2026</i>.