Data · dataset · 2026
Data from: Intermetallic nanoassemblies potentiate systemic STING activation
Listed in DataCite
Natural systems utilize metal ions in structurally ordered architectures to regulate essential biological processes, inspiring the rational design of nanostructures for therapeutic applications.
Description
The cGAS-STING pathway, a key mediator of innate immunity, detects cytoplasmic DNA and triggers type I interferon (IFN-I) responses essential for antitumor immunity. However, translating STING activation into effective cancer immunotherapy has been challenging due to poor pharmacological properties and systemic toxicity.
Here, we report CRYSTAL (Crystal-like STING-Activating nanoassemblies), a structurally ordered intermetallic nanoparticle platform for potent systemic STING activation. CRYSTAL was synthesized via self-assembly of manganese (Mn2+) ions intercalated with cyclic dinucleotides, wrapped within lipid layers. Computational modeling accurately predicted CRYSTAL’s self-assembly behavior, highlighting its tunability and design precision.
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At ultra-low doses, intravenous CRYSTAL administration effectively activated STING in mice, dogs, and non-human primates, and CRYSTAL demonstrated remarkable antitumor efficacy in late-stage murine and rabbit tumor models. Mechanistically, CRYSTAL reversed immunosuppressive tumor and spleen microenvironments and triggered robust CD8+ T cell priming in a host STING dependent manner. CRYSTAL also induced IFN-I responses in human head and neck squamous cell carcinoma (HNSCC) biopsies, underscoring its translational potential.
These findings establish structurally ordered metallo-nanostructures as a promising strategy for metalloimmunotherapy.
Links
Where it is published
- Repository landing page datadryad.org/dataset/doi:10.5061/dryad.qz612jmw8 ↗
landing page · from DataCite
- DOI doi.org/10.5061/dryad.qz612jmw8 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Zero v1.0 Universal creativecommons.org/publicdomain/zero/1.0/legalcode ↗
license · from DataCite
- IsCitedBy 10.1126/science.adx1893 doi.org/10.1126/science.adx1893 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.5061/dryad.qz612jmw8 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.5061/dryad.qz612jmw8 ↗
catalogue entry · from DataCite
Topics
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.5061/dryad.qz612jmw8 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| version_label | source · DataCite | connector:datacite@1.0.0 |