Identifying broad spectrum stress-responsive genes in Trametes versicolor to engineer enhanced tolerance to hydrothermal liquefaction aqueous phase

One such stream, hydrothermal liquefaction aqueous phase (HTL-AP), is a toxic yet nutrient- rich byproduct generated during conversion of biomass to biocrude oil. HTL-APs are chemically diverse, posing significant challenges to implementing robust treatment methods for detoxification and nutrient reclamation.

Fungi exhibit a wide breadth of metabolic capabilities that respond dynamically to their environment, making them a resilient and versatile solution for degrading or transforming recalcitrant compounds from streams such as HTL-AP. Understanding the genetic basis of fungal tolerance in such environments is critical to fully realize their bioremediation capacity. This work leverages transcriptomic analyses to identify key gene families broadly associated with fungal stress tolerance, providing insight into the molecular mechanisms driving acclimation to various inhibitors.