Omics · dataset · 2023
Mechanisms of polymyxin B resistance and heteroresistance in the sepsis pathogen Enterobacter bugandensis
Listed in Teesside University Research Data Repository
A major concern with the ESKAPE pathogen Enterobacter bugandensis and other species of the Enterobacter cloacae complex, is the frequent appearance of multidrug resistance against last-resort antibiotics, such as polymyxins.
Description
We investigated polymyxin B (PmB) resistance and heteroresistance in two E. bugandensis clinical isolates by global transcriptomics and deletion mutagenesis. The datafiles in this dataset include (i) genome annotations of E. bugandensis E105227, E. bugandensis E104107, and E. Ludwigii E6218; (ii) RNAseq data comparing plus or minus polymyxin B treatment for E105227 and E104107; (iii) Protein interaction network analysis on E105227 based on RNAseq informastion; (iv) MS data for the idfentificatino of proteins in co-immunoprecipitates.
Links
Where it is published
- DOI doi.org/10.17632/tpbv7bnh6n.2 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Mass spectrometry · RNA sequencing · Social Science
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/tpbv7bnh6n.2 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Mass Spectrometry'] |
| concepts[modality].local:modality:rna-seq | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['RNA Sequencing'] |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |