Table · dataset · 2026
Data Sheet 1_Circulating Helicobacter pylori extracellular vesicles in serum as biomarkers of infection.pdf
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<p>Gastric infection by Helicobacter pylori (H. pylori) is associated with extra-gastric pathologies.
Description
H. pylori can promote these pathologies by generating extracellular vesicles (Hp-EVs), which cross biological barriers and access other tissues through the circulation. However, the presence of Hp-EVs in the human circulation has not been demonstrated.
We isolated and characterized EVs from serum of non-infected and infected patients, and used immunoblots (IB) to identify markers from host cells EVs (h-EVs) and Hp-EVs. We also assessed the predictive capacity of IB with an anti-Urease subunit B (UreB) antibody to identify true positive cases of H. pylori infection. Finally, we compared the diagnostic utility of IB-UreB with other detection methods of H. pylori in blood samples.
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Thirty symptomatic individuals underwent endoscopy, gastric biopsy and blood tests. Rapid Urease test (RUT), pathological analysis and Gastropanel® (GP) classified 16 cases (53.3%) as H. pylori positive. EV markers CD63 and CD81 were detected in all the isolated EVs from the serum of these patients.
Moreover, UreB+ EVs were detected in 62.5% of H. pylori-infected patients, providing the first evidence of circulating Hp-EVs in human serum. Among the blood biomarkers evaluated, IB-UreB+ proved to be the best method for diagnosing H. pylori-positive cases. Furthermore, combining IB-UreB+ with GP increased its diagnostic value.
Our findings provide the first evidence of circulating Hp-EVs in human serum, thereby supporting a mechanism for systemic dissemination of bacterial virulence factors. Additionally, their detection in blood samples may enable minimally invasive diagnosis of H. pylori infection.</p>
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Where it is published
- DOI doi.org/10.3389/fcimb.2026.1893888.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
Provenance · 1 source records, 17 field assertions
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