Constarium
← Search

Data · dataset · 2025

Data for: A Morphology-Based Machine Learning Model for Scoring Epithelial-Mesenchymal Plasticity using Organelle Dynamics

Listed in Researchdata.se

Description

Project

Description: This project is aimed at modelling dynamic organelle morphology changes in a cellular model of epithelial-mesenchymal transition (EMT). EMT is a developmental process, which is re-activated in cancer and promotes invasion, metastasis and resistance to various therapies. The repository contains raw microscopy images (.nd2 files) and numerical data outputs of all the experiments performed on a variety of cell lines (breast cancer, lung cancer).

Read the rest (1 more)

Cells were stained with the CellPainting kit. Experiments codes are listed below. Categories: Translational and applied bioinformatics; Cellular interactions (incl. adhesion, matrix, cell wall) Numerical Data Source_wet lab + database (782.78 KB) (1 excel file with numerical data source for MS experiments; 1 pdf file with WB uncropped membranes images) Numerical Source Data_all CP experiments (microscopy): (14.47 GB) - CP015/016/018: NMuMG training set (cellprofiler outputs) - CP017: NMuMG reversal experiment - CP019:NMuMG model validation - CP020: breast cancer cells - CP_INT_03_Normoxia: A549 Normoxia - CP_INT_03_Hypoxia: A549 Hypoxia Images (.ND2 files): - CP015_nd2 (37.24 GB): NMuMG training set.1 - CP016_nd2 (37.24 GB): NMuMG training set.2 - CP018_nd2 (37.24 GB): NMuMG training set.3 - CP017_nd2 (37.24 GB): NMuMG reversal experiment - CP019_nd2 (37.24 GB): NMuMG model validation - CP020_nd2 (37.24 GB): breast cancer cells - CP_INT_03_Normoxia_nd2 (18.62 GB): A549 Normoxia - CP_INT_03_Hypoxia_nd2 (18.62 GB): A549 Hypoxia Image files are in nd2 format, which is Nikon's proprietary format, but can be viewed with open source tools such as ImageJ.

Links

Where it is published

Catalogue records · 1

Topics

Inferred from text
Cancer 75% · Image 75% · Microscopy 75% · Structural biology 76%
Provenance · 1 source records, 13 field assertions
SourceKeyLast seenRaw
Researchdata.seoai:researchdata.se:2025-306/111 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · researchdata seconnector:researchdata_se@1.0.0
concepts[disease].local:disease:cancerenrichment · researchdata sekeyword-concept-rules@1.0.0title+description (75%)
concepts[field].anzsrc:field:310112enrichment · researchdata setaxonomy-embedding@1.1.0title+keywords+description (76%)
concepts[field].local:field:earth-environmentalmapping · researchdata seconnector:researchdata_se@1.0.0
concepts[field].local:field:life-sciencesmapping · researchdata seconnector:researchdata_se@1.0.0
concepts[field].local:field:medicine-healthmapping · researchdata seconnector:researchdata_se@1.0.0
concepts[modality].local:modality:imageenrichment · researchdata sekeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:microscopyenrichment · researchdata sekeyword-concept-rules@1.0.0title+description (75%)
descriptionsource · researchdata seconnector:researchdata_se@1.0.0/metadata/dc/description
license_textsource · researchdata seconnector:researchdata_se@1.0.0
publication_datesource · researchdata seconnector:researchdata_se@1.0.0
spatialsource · researchdata seconnector:researchdata_se@1.0.0
titlesource · researchdata seconnector:researchdata_se@1.0.0/metadata/dc/title