Data · dataset · 2018
Impact of surface topography on biofilm formation by Candida albicans
Listed in DataCite
Candida albicans is a fungal pathogen that causes serious biofilm-based infections.
Description
Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC5314 on a series of polydimethylsiloxane (PDMS) solids.
The surfaces were prepared with monolayer coatings of monodisperse spherical silica particles that were fused together into a film using silica menisci. The surface topography was varied by varying the diameter of the silica particles that were used to form the film. Biofilm formation was observed to be a strong function of particle size.
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In the particle size range 4.0–8.0 µm, there was much more biofilm than in the size range 0.5–2.0 µm. The behavior of a clinical isolate from a clade separate from SC5314, strain p76067, showed results similar to that of SC5314. Our results suggest that topographic coatings may be a promising approach to reduce C. albicans biofilm infections.
The data set contains the image files obtained using confocal microscopy.
Links
Where it is published
- Repository landing page data.lib.vt.edu/articles/dataset/Impact_of_surface_topography_on_biofilm_forma… ↗
landing page · from DataCite
- DOI doi.org/10.7294/w4d21vrb ↗
DOI / persistent id · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.7294/w4d21vrb ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.7294/w4d21vrb ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Chemical engineering
- From keywords
- Chemical engineering
- Inferred from text
- Image 75% · Microscopy 75%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.7294/w4d21vrb | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].fos:chemical-engineering | source · DataCite | connector:datacite@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:microscopy | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |