Lycium barbarum polysaccharide-glycoprotein ameliorates abnormal neural activity in depressive patient-derived ventral forebrain organoids

Despite considerable advances in research, most current treatments for depression remain ineffective for many patients. Given the potential antidepressant properties of Lycium barbarum glycopeptide (LbGp), there is an urgent need to establish a platform for evaluating its therapeutic efficacy and underlying mechanisms.

In this study, we generated ventral forebrain organoids derived from MDD patient and observed abnormal neuronal morphology along with impaired calcium dynamics and electrical activity. Treatment with LbGp effectively restored these phenotypic alterations in MDD organoids. Transcriptomic analysis further revealed that LbGp could ameliorate endoplasmic reticulum (ER) stress in MDD organoids.