Data · dataset · 2026
Estrogen and progesterone receptor signaling as candidate neuroendocrine modulators in Huntington’s disease
Listed in ZivaHub and Deakin Research Online — shown once because both records carry DOI 10.6084/m9.figshare.34030115.v1
<p>Huntington’s disease (HD) is a genetically driven neurodegenerative disorder marked by progressive corticostriatal dysfunction, excitotoxicity, mitochondrial impairment, and neuroinflammation.
Description
Disease-modifying therapies remain limited, and the receptor-specific relevance of neuroendocrine signaling is poorly defined.</p> <p>This review evaluates estrogen receptor beta (ERβ), G-protein–coupled estrogen receptor 1 (GPER1), and progesterone-derived neurosteroids, particularly allopregnanolone, as candidate modulators of HD vulnerability.
A structured search of PubMed, Web of Science, and Scopus covered studies published from January 1, 1990, through October 1, 2025, supplemented by manual reference screening. Evidence from patients and HD models is prioritized; mechanistic findings from other neurodegenerative and excitotoxic models are interpreted cautiously.</p> <p>We examine receptor-specific effects on glutamatergic signaling, mitochondrial bioenergetics, microglial activation, oxidative stress, and transcription, including potential disruption of estrogen-responsive pathways by mutant huntingtin.
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Sex differences, hypothalamic–pituitary–gonadal axis disturbances, and neurosteroid fluctuations are also considered.</p> <p>Finally, we assess SERMs, ERβ-selective agonists, and progesterone-based strategies as hypothesis-driven adjuncts—not established treatments—while addressing thromboembolic risk, endocrine contraindications, CNS penetration, receptor selectivity, and drug interactions. This synthesis identifies evidence gaps and proposes testable questions for early-phase translational research.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34030115.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Biochemistry and cell biology · Cancer · Cancer · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Genetics · Genetics · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Research, science and technology policy · Research, science and technology policy
- Inferred from text
- Disease 75%
Provenance · 2 source records, 22 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34030115 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34030115 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |