Tumors hijack erythropoiesis for myelopoiesis and immunosuppression

Here, using lineage tracking in cancer patients and tumor-bearing mice, we demonstrate that erythroid progenitor cells lose their developmental potential and switch to the myeloid lineage.

Single-cell transcriptome analyses reveal that, notwithstanding quantitative differences in erythroid gene expression, erythroid differentiated myeloid cells (EDMCs) are transcriptionally indistinguishable from their myeloid-originated counterparts. EDMCs possess multifaceted machinery to curtail T cell-mediated anti-tumor responses. Consequently, the EDMCs content within tumor tissues is negatively associated with T cell inflammation for the majority of solid cancers; moreover, EDMCs enrichment, in accordance with anemia manifestation, is predictive of poor prognosis in various cohorts of patients undergoing ICIs therapy.