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Omics · dataset · 2025

Expression data from major metabolic organs of C57BL/6J mice and MIN6 cells maintained on normal or stressed conditions

Listed in Teesside University Research Data Repository

We studied the novel mechanism of ER quality control, ER homeostasis maintenance and functional plasticity in pancreatic β-cells to increase systemic glucose homeostasis against progression of type 2 diabetes.

Description

In RNA-Seq dataset, we provided islets' RNA-Seq for C57BL/6J wildtype mice on 2-month high-fat diet and on normal chow diet; we also provided 10 different metabolic tissues' RNA-Seq for C57BL/6J wildtype mice on normal chow diet.

In proteomics dataset, we provided proteomic analysis on MIN6 cells and supernatant on normal and stressed culturing conditions; we also provided islets' proteomic analysis for C57BL/6J wildtype mice on 2-month high-fat diet and on normal chow diet; we also provided proteomic analysis for DNA-pull down-protein complex from HEK293T cells. Original computational code for image processing were deposited in this dataset. All the algorithms were implemented with OpenCV and Numpy library in Python.

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Where it is published

Catalogue records · 1

Topics

Inferred from text
Image 75% · RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
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Teesside University Research Data Repositoryoai:data.mendeley.com/yx33pt7t4f.117 h agoJSON v1
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concepts[field].local:field:earth-environmentalmapping · researchdata tees ac ukconnector:researchdata_tees_ac_uk@1.0.0
concepts[modality].local:modality:imageenrichment · researchdata tees ac ukkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:mass-spectrometrymapping · researchdata tees ac ukvocabulary-mapper@1.0.0keywords['Proteomics']
concepts[modality].local:modality:rna-seqenrichment · researchdata tees ac ukkeyword-concept-rules@1.0.0title+description (65%)
concepts[modality].local:modality:sequencingmapping · researchdata tees ac ukvocabulary-mapper@1.0.0keywords['Next Generation Sequencing']
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