Mechanism of Zishen Huoxue Formula in improving cognitive impairment in rats with vascular dementia by regulating the AMPK/PGC-1α Signaling pathway-raw data

Previous research by the research group has shown that the Kidney Nourishing and Blood Activating Formula can reduce the levels of reactive oxygen species (ROS) in the hippocampus of VD rats. Research has shown that mitochondria, as the main source of live ROS, exhibit ROS accumulation when their function is impaired, causing oxidative stress damage to mitochondria and ultimately leading to ferroptosis. At present, it is not clear whether the Zishen Huoxue Formula promotes mitochondrial biosynthesis by activating the AMPK/PGC-1 α pathway, thereby inhibiting ferroptosis to prevent VD.

Based on this, this study intends to explore the mechanism of Zishen Huoxue Formula in protecting hippocampal neurons in VD rats from the perspective of "AMPK/PGC-1 α pathway regulating mitochondrial biosynthesis and inhibiting ferroptosis".