Data · dataset · 2026
Engineering sustained release drug delivery systems for treatment of chronic bone disorders
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32805872.v1
Bone disorders including osteoporosis, rheumatoid arthritis, and osteoarthritis represent significant global health burdens.
Description
Current therapeutic approaches are limited by poor bioavailability, rapid systemic clearance, adverse effects, and low patient compliance. Mesoporous silica nanoparticles (MSNs) offer a promising solution through targeted, sustained-release delivery systems that can improve treatment efficacy while minimizing side effects.
This thesis describes the development and characterization of MSN-based nanocarriers for dual delivery of alendronate (ALD), a bone-targeting bisphosphonate, and osteogenic growth peptide (OGP10-14), a peptide promoting bone formation. MSNs were synthesized and functionalized with amine groups via (3-aminopropyt)triethoxysilane (APTES) to enable both physical adsorption and chemical conjugation of therapeutic agents. Comprehensive physicochemical characterization employed transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) analysis to assess structural properties and thermal stability.
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Validated analytical methods based on UV-Visible spectrophotometry and high-performance liquid chromatography (HPLC) were developed for accurate ALD quantification. OGP (10-14) was synthesized via solid-phase peptide synthesis and characterized by mass spectrometry and NMR. Dual-loaded nanoformulations were prepared using carbamate linker chemistry for chemical conjugation and physical adsorption. <br><br>Biological evaluation using MG-63 osteoblast cells demonstrated excellent biocompatibility and efficient cellular uptake via confocal microscopy.
Cell proliferation assays showed enhanced osteoblast growth, while mineralization assays revealed that chemically conjugated OGP (10-14)@ALD-MSN formulations significantly increased calcium deposition and mineral nodule formation compared to physically loaded systems. <br><br>The results demonstrate that MSN-based dual-delivery systems effectively combine sustained-release kinetics with enhanced osteogenic activity. These nanocarriers show considerable promise for treating bone disorders through localized, targeted delivery.
Future work should focus on sterilization, scale-up manufacturing, long-term stability studies, and in vivo efficacy evaluation prior to clinical translation.<br><br><i>Thesis is embargoed until 31 July 2029.</i>
Links
Where it is published
- DOI doi.org/10.17034/32805872.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Mass spectrometry 75% · Microscopy 75%
Provenance · 3 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32805872 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32805872 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32805872 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:microscopy | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |