Data · dataset · 2025
Trem2 prevents adverse pregnancy outcomes induced by Toxoplasma gondii by promoting PPARγ-mediated P-STAT6 signaling
Listed in Teesside University Research Data Repository
Decidual macrophages (DMs), required for the maintenance of a successful pregnancy, are vital target cells for Toxoplasma gondii (T. gondii) during adverse pregnancy induced by T. gondii.
Description
Trem2 is a functional immune receptor on the surface of DMs, governing cell survival and phagocytosis. Our previous study demonstrated that Trem2 deficiency aggravates T. gondii-induced adverse pregnancy outcomes.
However, Trem2-related downstream signaling pathways in T. gondii-induced adverse pregnancy outcomes remains unclear. Here, we demonstrated a significant decrease in PPARγ and phosphorylated-STAT6 (P-STAT6) in mouse placentas following T. gondii infection. By using a Trem2 knockout mouse model, we found that Trem2 deficiency failed to affect the expressions of P-STAT6 and PPARγ in infected mouse placentas, peritoneal macrophages and bone marrow-derived macrophages (BMDMs).
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Consistently, overexpression of Trem2 in macrophages significantly activated the downstream signaling pathway and partially reversed the inhibitory effects of T. gondii antigens on P-STAT6 and PPARγ, similar to the effect of PPARγ agonists. Altogether, our study identified Trem2 as a key regulator of PPARγ-mediated P-STAT6 signaling pathways in adverse pregnancy outcomes due to T. gondii infection. Our novel findings concerning Trem2 and its downstream PPARγ-mediated P-STAT6 signaling pathways might provide new preventive and therapeutic targets for toxoplasmosis.
Links
Where it is published
- DOI doi.org/10.17632/7dy5ywnfv3.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science
Related
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/7dy5ywnfv3.1 | 15 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |