Transcriptomic profiling of C6/36 cells treated with the METTL3 inhibitor STM2457

Before these viruses can spread to humans, they must successfully replicate inside mosquito cells. Understanding how mosquitoes naturally control viral infections can reveal new ways to limit disease transmission.

This study explores how a common chemical modification of RNA, known as m6A, helps regulate virus infection in mosquito cells. By uncovering how RNA modifications affect viral infection in mosquitoes, this work provides new insights into the biology of disease transmission and identifies potential targets for future strategies to reduce the spread of mosquito-borne viruses.