Table · dataset · 2026
<p>Overview of the flywheel training program for PD.</p>
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<div><p>Exercise is a promising non-pharmacological intervention for motor and non-motor symptoms in Parkinson’s disease (PD).
Description
However, direct comparisons between basic physical training (BPT) and dual-task training remain limited. The objective of the current clinical trial is to evaluate clinical and functional effects of BPT and a BPT combined with dual-task functional exercises (BPT + FE) in individuals with PD.
In this randomized controlled trial, 24 participants with idiopathic PD were allocated to BPT, BPT + FE, or a no-intervention control group (Con). Interventions lasted 12 weeks (three 60-minute sessions/week). Outcomes included quality of life (PDQ-39), depressive symptoms (BDI), lower-limb strength (1-minute Sit-to-Stand Test, STS), and functional mobility (Timed Up and Go, TUG).
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Group effects were analyzed using permutation-based ANOVA with Bonferroni correction. Both interventions significantly improved physical performance vs. controls. STS gains were observed for BPT vs. Con (Mean Difference, MD = 31.00; p = .0026) and BPT + FE vs. Con (MD = 19.00; p = .0026).
TUG times improved for BPT vs. Con (MD = –2.07s; p = .0039) and BPT + FE vs. Con (MD = –2.43s; p = .0028). Although BDI and PDQ-39 did not show statistically significant changes between group differences (r_rb = –0.429 and –0.339, respectively), several subscales demonstrated medium effect sizes suggesting potentially meaningful trends: emotional well-being (BPT: r_rb = –0.428; BPT + FE: r_rb = –0.446), bodily discomfort (BPT: r_rb = –0.524), and activities of daily living (BPT + FE: r_rb = –0.429).
In conclusion, both programs improved physical performance in PD. Patient-reported outcomes did not reach statistical significance, but effect-size patterns suggest possible psychosocial benefits that warrant confirmation in larger trials.</p><p>Trial registration</p><p>ClinicalTrials.gov, <a href="clinicaltrials.gov/ct2/show/NCT05963425" target="_blank">NCT05963425</a>.</p></div>
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Where it is published
- DOI doi.org/10.1371/journal.pone.0358534.t001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Computer Science & AI · Earth & Environmental Science · Economics & Finance · Engineering · Humanities · Life Sciences · Mathematics & Statistics · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science
- Inferred from text
- Disease 75% · Sports science and exercise 71%
Provenance · 1 source records, 20 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33937943 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · figshare com | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:4207 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (71%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |