<p>NHR-10 and NHR-68 inhibit innate immune response.</p>

<p><b>(A)</b> Representative fluorescence micrographs of <i>clec-60p::gfp</i> animals grown on <i>E. coli</i> HT115 carrying empty vector or RNAi against <i>nhr-77</i>, <i>nhr-10</i>, <i>nhr-130</i>, <i>nhr-222</i>, <i>nhr-162</i>, <i>nhr-42</i>, <i>nhr-140</i>, <i>nhr-68</i>, or <i>nhr-10</i> and <i>nhr-68</i> (<i>n</i> = 8 animals per condition per experiment; <i>N</i> = 3 independent experiments). Fluorescence images were captured with 100-ms exposures.

Scale bar, 200 µm. <b>(B)</b> qRT–PCR analysis of the immune gene <i>clec-60</i> in wild-type, <i>nhr-10(tm4695)</i>, <i>nhr-68(gk708)</i> and <i>nhr-10(tm4695)</i>; <i>nhr-68(gk708)</i> animals fed on <i>E. coli</i>. Data are presented as the mean ± SD from three independent biological replicates (<i>N</i> = 3; <i>n</i> = 200 animals per condition per biological replicate). ***<i>p</i> < 0.001, one-way ANOVA with Tukey’s multiple-comparison test. <b>(C)</b> Survival of WT, <i>nhr-10(tm4695)</i>, <i>nhr-68(gk708)</i> or <i>nhr-10(tm4695)</i>;<i>nhr-68(gk708)</i> animals grown on <i>P. aeruginosa</i> at 25 °C. Mean survival times were 2.06, 2.36, 2.82, and 3.13 days, respectively.