Pregnancy-acquired memory CD4+ regulatory T cells in human PBMCs

They represent the raw data files for flow cytometry data published in Figure 1 of the publication "Pregnancy-acquired memory CD4 + regulatory T cells improve pregnancy outcome in mice" by Thiele, K. et. al. published in Nature Communication (DOI: 10.1038/s41467-025-61572-w). Abstract of the publication: Subsequent pregnancies are generally less prone to obstetric complications.

A successful pregnancy outcome requires pivotal immunological adaptation to ensure immune tolerance towards the fetus. Thus, the lower risk for pregnancy complication during subsequent pregnancies may be attributable to immune memory mounted during first pregnancies. Here we identify higher frequencies of fetal-antigen-specific CD4 + regulatory T (Treg) cells both postpartum and in subsequent pregnancies in mice which are partly originating from trans-differentiated Th17 cells.